Periodontal Pathogens and Carcinogenesis


Is there any evidence to support a potential link?

by dr kishan sheth

part one – bibliography

  1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–1820.
  2. U.S. Department of Health and Human Services. Oral health in America: A report of the surgeon general. Rockville, Md.: U.S. Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health; 2000. Available at: “ library/oralhealth/”. Accessed June 22, 2006.
  3. William Hunter. Quoted by: O’Reilly PG, Claffey NM. A history of oral sepsis as a cause of disease. Periodontology 2000 2000;23:13-8.
  4. Thodden van Velzen SK, Abraham-Inpijn L, Moorer WR. Plaque and systemic disease: a reappraisal of the focal infection concept. J Clin Periodontol 1984;11(4):209-20.
  5. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol. 2000. 2005;38:135–187.
  6. Abusleme L, et al. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 2013;7:1016–1025.
  7. Manoj Kumar, Prasanta Bandyopadhyay, Lora Mishra, Satadal Das, Prabir Kumar Kundu, Surajit Mistry, Effect of periodontal therapy on glycemic control and circulating TNF-α in type 2 diabetic patients, International Journal of Diabetes in Developing Countries, 2015, 35, 2, 96.
  8. Dhadse P, Gattani D, Mishra R. The link between periodontal disease and cardiovascular disease: How far we have come in last two decades ? Journal of Indian Society of Periodontology. 2010;14(3):148-154. doi:10.4103/0972-124X.75908.
  9. Farrell S, Ide M, Wilson RF.The relationship between maternal periodontitis, adverse pregnancy outcome and miscarriage in never smokers. J Clin Periodontol. 2006 Feb; 33(2):115-20.
  10. Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol. 1999;70:793–802.
  11. von Wowern N, Klausen B, Kollerup G. Osteoporosis and periodontal disease. J Periodontol. 1994 Dec;66(12):1134–8.
  12. Moore WE, Moore LV. The bacteria of periodontal diseases.Periodontol 2000. 1994 Jun; 5():66-77.
  13. Genco RJ. Host responses in periodontal diseases: current concepts. J Periodontol 1992: 53:338-355.
  14. Consensus Report for Periodontal Diseases: pathogenesis and microbial factors. Ann Periodontol 1996: 1: 92G932.
  15. Williams RC. Periodontal disease. N Engl J Med 1990: 322: 373-382.
  16. H. G. Ren, H. N. Luu, H. Cai, Y. B. Xiang, M. Steinwandel, Y. T. Gao, M. Hargreaves, W. Zheng, W. J. Blot, J. R. Long, X. O. Shu; Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis. Ann Oncol2016; 27 (7): 1329-1336. doi: 10.1093/annonc/mdw172
  17. Laprise, C., Shahul, H. P., Madathil, S. A., Thekkepurakkal, A. S., Castonguay, G., Varghese, I., … Nicolau, B. (2016). Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. International Journal of Cancer, 139(7), 1512-1519. DOI: 10.1002/ijc.30201
  18. Christian C Abnet, You-Lin Qiao, Sanford M Dawsey, Zhi-Wei Dong, Philip R Taylor, Steven D Mark; Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol2005; 34 (2): 467-474. doi: 10.1093/ije/dyh375
  19. Miyazaki Y, Kikuchi K, González-Alva P, Inoue H, Noguchi Y, et al. (2010) Association of Butyric Acid Produced by Periodontopathic Bacteria with Progression of Oral Cancer. J Cancer Sci Ther 2: 026-032. doi:10.4172/1948-5956.1000019
  20. Goyal, Sachin et al. “Stress and Periodontal Disease: The Link and Logic!!” Industrial Psychiatry Journal22.1 (2013): 4–11.
  21. Eke PI, Genco RJ (2007). CDC periodontal disease surveillance project: background, objectives, and progress report. J Periodontol 78(7 Suppl):1366S-1371S.





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